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The Gigacrop team. L-R: Senior Scientist Michael Dougherty, CEO Chris Eiben, Head of Protein Engineering Juhan Kim, Research Associate III Victor Vela, Scientist II Rahman Pour.

GigaCrop’s Chris Eiben wants to improve photosynthesis. Here’s how he’s doing it.

“The thing holding plants back today is the enzyme Rubisco,” Eiben says. “It’s the first enzyme a plant uses to take CO2 and start turning it into a sugar. But the enzyme is slow, and it has a tendency to use oxygen instead of CO2 . Which is incredibly costly for the plant to fix. I don't have a clever way to make Rubisco better; land plants have been trying to improve it for 450 million years, which is a long time. Doing better than that is tough. So GigaCrop is inserting a parallel photosynthesis pathway into plants. “If a plant were an airplane, what we are doing is installing a more efficient engine. The trick is we have to do it while the airplane is flying. Plants must have a working engine at all times” he says. “Rubisco is part of a larger cycle called the Calvin-Benson cycle. Our pathway can exist next to the Calvin-Benson cycle, and they can both operate. But the plants will benefit because our pathway is faster and more energy efficient.”

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Valitor Team

Tenant Spotlight: Valitor Aligns Its Stakeholders to Develop Biopolymer Therapeutics

“Getting the science right is hard enough, but at least I was trained to be a scientist,” says CSO and former CEO Wesley Jackson. “The skill that I had to learn the quickest was to keep all the company’s stakeholders aligned. I naively assumed that if the science was great enough, it would be sufficient to launch the business. But, instead, I found that a company can only exist because there is a team of people who have an interest in it existing." Read post
Perlumi's Chris Eiben at the bench.

Tenant Spotlight: Perlumi’s Plan to Perfect Photosynthesis 

“We can’t make more land, so we need to be more efficient with it. One way to do this is to make plants fundamentally better at photosynthesis. If you make photosynthesis better, you solve a lot of problems at the same time. You increase food security, you can pull CO2 out of the atmosphere for the long term, and you can spare land for biodiversity.”  Read post
The Catena team (L-R: Samantha Brady, Chanez Symister, Maxwell Nguyen, Marco Lobba) at the opening launch event for Bakar Labs and the Bakar BioEnginuity Hub. UC Berkeley photo by Keegan Houser.

Tenant Spotlight: Catena Biosciences and Next-Generation Protein Coupling

How can we direct therapeutics to where we want them to take effect? Often the solution lies in attaching, or conjugating, a therapy to another molecule that performs the targeting function. “We discovered a new protein conjugation process that allowed us to build things like CRISPR base editors,” says Catena CEO and co-founder Marco Lobba. “It’s not just applicable to Cas9, but also to antibodies, cell-based therapies, and several other types of new drugs." Read post