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Ali Madani, Profluent CEO

‘If You Could Hallucinate a Protein’: Profluent Snags $35M for Generative AI Models

In January 2023, Profluent’s large language model was detailed in a Nature Biotechnology paper, showing that it could create new proteins that functioned like ones found in nature. The upstart was founded by CEO Ali Madani, a former leader of machine learning work at Salesforce Research, and University of Washington School of Medicine assistant professor Alexander Meeske. Read post
Screenshot of the Profluent homepage. "Decoding the language of life with AI"

Profluent Secures $35M in Additional Funding and Key Industry Experts to Scale Foundational AI Models for Biomedicine and Tackle First Vertical in Gene Editing

“Our research at the forefront of AI has enabled Profluent to create large language models that begin to learn the blueprint of nature,” said Ali Madani, Profluent co-founder and Chief Executive Officer. “We are moving biology from being constrained by what can be discovered in nature to being able to design precisely according to our needs via AI. The science is real and the time is now to proactively create breakthrough medicines that can transform society.” Read post
Jenny Hamilton at the Innovative Genomics Institute. Photo by Adam Pardee at the San Francisco Business Times

Jenny Hamilton, CEO of Stealth Startup, Featured in Story of Jennifer Doudna’s Women in Enterprising Science Incubator

With its second cohort of young women scientists testing their problem-solving skills and entrepreneurial ambitions, the HS Chau Women in Enterprising Science Program within Nobel laureate Jennifer Doudna’s Innovative Genomics Institute is giving rise to a new generation of biotech startups. At the same time, the program is solidifying Doudna’s legacy. Read post
Tim Craven

Dupixent in a Pill? Startup Insamo Will Try To Turn Blockbuster Biologics Into Orals

Berkeley, CA-headquartered Insamo was founded in 2022 by a trio of PhD scientists, who have raised a $12 million seed round that includes investors like venBio and Playground Global, CEO Tim Craven told Endpoints News exclusively. The board includes Playground’s venture partner Matt Hershenson and is chaired by venBio managing partner Corey Goodman. Insamo is developing macrocyclic peptides, which look like ring-shaped mini-proteins. They aim to have the potency of antibody drugs while being small enough to stay orally bioavailable, meaning they could be taken as pills rather than injections or infusions. Read post
Shakked Halperin

Rewrite and Replace: Shakked Halperin, Serial Entrepreneur

“CRISPR offered a pair of DNA scissors that were going to change the world,” Shakked says. “But I didn’t want to just cut. I wanted to rewrite with full control over the target sequence, so with Rewrite I turned to nature’s DNA writer – DNA polymerases – and made something closer to a pencil.” Read post
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