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Synthetic proteins are being built with the help of AI models

Others are taking a slightly different tack. Profluent, in Emeryville, California and EvolutionaryScale, in New York, are building protein-design AI models that resemble not image-generating software, but large language models (LLMs) of the sort that power the world’s chatbots. These firms’ models treat the amino-acid sequences in protein chains like the words in a piece of text—analysing relationships found in zillions of exemplars to design novel useful structures. According to Ali Madani, Profluent’s chief executive, the firm is particularly focused on creating new CRISPR-Cas gene-editing tools. Here, its USP is a curated database of around 5m CRISPR-Cas protein complexes on which its AI model has been trained in order to design new versions.

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Vicinitas Therapeutics Launches With $65 Million in Series A Financing to Advance Precision Medicines to Stabilize Key Proteins to Treat Disease

“The concept of chemically induced proximity – using multispecific molecules to bring two targets physically together – has yielded notable successes in the field of protein degradation,” said Jorge Conde, General Partner at a16z. “Vicinitas is leveraging its proprietary DUBTAC platform to pioneer the emerging space of targeted protein stabilization. This approach has the potential to access highly valued yet currently undruggable proteins and create differentiated therapies that will impact patient lives.” Read post
Derek Sims, Cornell Mallari, and Terry Hermiston of Coagulant in the lab

Coagulant Therapeutics Announces Publication of In Vivo Data Demonstrating Safety and Efficacy of CT-001 for the Management of Acute Bleeding

Uncontrolled bleeding is the single largest cause of death among individuals ages 1 to 44 years. In fact, 40% of all trauma deaths are a result of blood loss. And yet, on the other side of the spectrum, blood clots can lead to another set of serious health problems. That’s why Coagulant is developing CT-001, a recombinant coagulation factor that circulates in the blood for only 3 minutes. Read post
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Is Seaweed the Next Big Alternative to Meat?

Smithsonian Magazine covers the emerging sector of foodtech companies, including Bakar Labs tenant Umaro Foods, making delicious products from one of the world's great underused resources: kelp. Umaro CEO Beth Zotter says “[Bacon is] a product notorious for being hard to give up for vegetarians. It’s sort of like the gateway drug that makes people revert back to full-on carnivory." Read post
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ResVita Bio receives Rare Pediatric Disease Designation for RVB-001 as a Treatment for Netherton Syndrome

"The physical and emotional challenges of chronic skin diseases are devastating to patients, particularly children" said Amin Zargar, Chief Executive Officer of ResVita Bio. "Newborns with Netherton Syndrome face a severe lifelong disease with few treatment options that offer limited efficacy. We are motivated by the prospect to deliver meaningful improvement in the lives of these patients, and this is a significant step towards the development RVB-001 as a treatment for Netherton Syndrome." Read post
Josh Yang of Glyphic Bio in their lab at Bakar Labs

How Berkeley Is Leaning in to the Biotech Boom

"Nowadays, they meet in person at the Bakar BioEnginuity Hub, the recently completed lab and office space that is emblematic of UC Berkeley’s efforts to support bioscience startups. It’s part of a web of startup activity on campus that’s so vast, the university created a website to help people navigate it." Read post